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However, despite all these differences there is still a biological plausibility of a link between B 12 and depression given that B 12 is a necessary co-factor for methionine synthesis which provides methionine, the precursor of S-adenosylmethionine that is then needed for the formation of important brain neurotransmitters such as dopamine and norepinephrine (Reference Bailey, Stover and McNulty18,Reference Bottiglieri and Reynolds19)

Its a small molecule a quinolinium derivative with a molecular weight around 159 to 175 Da

It circulates in plasma, appears in urine and saliva, and is thought to play a physiological role in tissue repair and cellular signaling

Sun X, Li C-W, Wang W-J, Chen M-K, Li H, Lai Y-J, Hsu JL, Koller PB, Chan L-C, Lee P-C, et al

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