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References Rat anabolic/nitrogen retention dosing including des(13) IGF1 ~1.08 mg/kg/day Nephrectomized rat model des(13) IGF1 0.9 mg/kg/day for 7 days Des(13) IGF1 additional rat dosing example 1.2 mg/kg/day Invitro concentration range example 6.753 nM Biodistribution/clearance considerations for labeled des(13) IGF1 Research Resources Follistatin 344 (FS344) Human dosage only (what's actually in clinical studies) Quickstart Highlights Compound (Human clinical form): rAAV1.CMV.huFS344 (AAV1mediated follistatin FS344 gene transfer) Route used in trials: Intramuscular (IM) injections into targeted muscles How dosing is expressed: vector genomes per kilogram (vg/kg) (not mg) Human trial doses reported: 6 10 vg/kg and 1.2 10 vg/kg (BMD cohorts)

Importantly, HGF-cMet signaling is crucial for maintaining cellular redox balance, with HGF acting as an antioxidant and c-Met signaling crucial to limiting the overproduction of endogenous ROS (Gloire et al

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JIMD Rep 38:16