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Sleep Med Clin 10:423434

Additionally, the vitamin antioxidant literature is mixed: a small, randomized ascent to Everest Base Camp suggested lower Lake Louise scores and higher SpO 2 with vitamins C/E plus lipoic acid, whereas a larger placebo-controlled expedition to 5200 m found no preventive benefit from oral antioxidants

Future research should therefore prioritize standardized methodologies, large-scale human intervention studies, mechanistic investigations at the molecular level, and comprehensive safety assessments to enhance the translational applicability of Spirulina in functional food systems

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Moreover, the mechanisms of lipid metabolism acting directly or indirectly on SLE are complex, and multiple factors have been implicated