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2016, 578 pages

Gli autori di una meta-analisi del 2013 hanno combinato i risultati di questo studio con quelli di 12 studi pi piccoli

Clinical manifestations of ascorbic acid deficiency in man

[14] A 2018 systematic review and meta-analysis of 12 randomized controlled trials found "supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects." The review also indicates that "the effect of ALC in younger subjects was not more effective than placebo in improving these symptoms." indicating a need for more research explaining the age/effect relation