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However, as a macromolecular peptide, insulin possesses inherent limitations, such as its large size, poor lipid solubility, and susceptibility to degradation

(eds) Advances in NADPH Oxidases Research: From Molecules to Diseases

Co-treatment with cellular antioxidant agents including EUK-134 (6), resveratrol (84), curcumin (9), CoQ10 (90), dimethyl fumerate (DMF) (95), melatonin (64, 159), and -lipotic acid (160, 161), as well as mitochondrially specific antioxidants including Trolox (14), mitoQ (70), Mito-Tempo (87), and elampimide (13, 87), have been demonstrated to reduce or completely abrogate mitochondrial lesions, including lipid peroxidation, intrinsic apoptosis, and impaired ATP production in both in vitro and in vivo rodent models

Hypopigmentation is characterized by patches of skin that are lighter in color than the surrounding skin

Vulliamy T, Kaeda J, Ait C

Management also includes CT or MRI to rule out optic neuropathy from compression related to the enlargement of the extraocular muscles