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Despite the previously mentioned challenges, there are additional obstacles

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There is also emerging evidence that vitamin B12 could modulate the immune system, possibly affecting how we respond to COVID-19 infections [4, 9], or even to vaccination [10]

Intense exercise increases magnesium loss through sweat and urine

Similarly, severe heart failure or pulmonary edema represents a contraindication or strong precaution, as large amounts of glycine solution may expand intravascular volume and precipitate or worsen congestive heart failure or pulmonary congestion

A score 16 was used to define clinically significant depressive symptoms (Reference Vilagut, Forero and Barbaglia31)