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SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma

Cell Biophys

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Palmieri et al., 2010)

Generally, studies with NCMPs using drug-loaded nanoparticles aim to achieve a stable formulation with cellular uptake, long tissue retention times and sustained drug release

Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function