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The time course of change in the blood thiol redox state has not been documented in vivo and may be slower than the pyridine nucleotide redox state

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For example, the Wnt/-catenin signaling pathway plays a critical role in maintaining stemness by activating transcriptional programs that promote self-renewal and inhibit differentiation in both normal cells and CSCs

This work was supported in part by the Koch Institute Support (core) grant (NCI P30-CA14051)