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These include inhibitors such as pyrrolidine dithiobarbamate (PDTC) (Wetli et al., 2006) and benzylisothiourea (Zhang et al., 2012)

These effects were mediated by an increase in phosphorylation of mTOR and/or its downstream substrates, p70-S6 kinase (S6K) and the Eukaryotic translation initiation factor 4E-binding protein-1 (4E-BP1) [21]

Examples of pharmaceutical compositions are those that allow oral or parenteral administration by the intravenous, intramuscular, subcutaneous, or transdermal routes