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This is because implementation of such effects may involve not only the levels of REST expression but also post-translational modifications of REST as well as various cofactors necessary for this proteins function 71

They all mean the same two-compound protocol

Gradual Dose Escalation Gradual dose escalation proceeds with: Weeks 1-4: 1 mg once daily Weeks 5-8: 2 mg once daily Thereafter: Adjustment based on individual response and goals Dosing Frequency Options Dosing frequency most commonly involves once daily administration (morning or evening), with alternative protocols using 2-3 times per week at 2 mg per injection

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doi:10.3390/biomedicines11112925 11