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Interestingly, lipid changes in the peripheral lipidome of PD patients also generally correspond with changes seen in the brain

Induction of HO-1 expression by iron-containing porphyrin hemin and treatment with the CO donor CORM-A1 protects EAE mice from acute disease, showing improvement in clinical score and reduced incidence of disease infiltration by polymorphonuclear cells (123)

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The type of control and study location were identified as sources of high heterogeneity following subgroup analysis