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In these models, Cre recombinase is fused to a mutated estrogen receptor (ER T2 ) which retains Cre in the cytoplasm until the receptor binds its ligand, the selective estrogen receptor modulator TAM (Feil et al., 1997

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Further, given its potential proliferative effects, ipamorelin is not advised for subjects with cancerous conditions, as it might intensify disease progression