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These free iron ions can also enter mitochondria, spurring oxidative stress induction therein while impairing their function such that mitochondrial ROS production increases while mitochondrial respiration is impaired, with concomitant mitochondrial swelling and MMP depolarization (Wang et al., 2020)

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Its precise molecular mechanisms, especially the specific role iron plays, remain a central research focus (Linkermann et al., 2014)

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