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Modern pharmacological studies have reported that tetramethylpyrazine (TMP), an active metabolite in Ligusticum chuanxiong , possesses various physiological functions, including antioxidant capabilities, anti-inflammatory actions, anti-apoptotic characteristics, the ability to regulate autophagy, vasodilatory functions, modulation of angiogenesis, inhibition of mitochondrial damage, safeguarding of endothelial cells, and mitigation of vascular smooth muscle cell proliferation and migration, and also offers neuroprotective benefits ( in vivo experiments using a mouse model of focal ischemic stroke (IS), TMP upregulates the expression of monocyte chemoattractant protein-induced protein one to inhibit neuroinflammatory responses, while protecting the integrity of the BBB ( Ligusticum chuanxiong

and other metabolites, such as salicylic acid (SA)

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A week later, he had recurrence of symptoms with redness of the left eye followed by irritation, pain, photophobia, and blurry vision

Each step was followed by centrifugation at 600 g to collect the pellet