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2, the NADPH homeostasis is mainly regulated by several metabolic pathways and enzymes including NAD kinase (NADK), the pentose phosphate pathway (PPP), the folate-mediated one-carbon metabolism, malic enzymes (ME), the nicotinamide nucleotide transhydrogenase (NNT), cytosolic or mitochondrial NADP-dependent isocitrate dehydrogenase (IDH1 and IDH2), the glutamine metabolism, and the fatty acid oxidation (FAO)

Among the energy-supplying substances, glucose and lipids serve as the major sources of energy in our body, and in most cases, glucose oxidation keeps the priority [5]

Autophagy 18 , 12161239 (2022)

Egg makes it harder

However, after extending the ageing protocol to 21 days, embryo fumigation with NOx provided potential support for ROS scavenging through increased GPX-like activity

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