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People with ulcerative colitis, persistent diarrhea, and poor appetite may also require thiamin

AOD9604, while mechanistically intriguing, remains largely experimental and lacks the clinical validation and regulatory support necessary for mainstream use

Clinical implications of vitamin B12 as redox-active cofactor

Preclinical models and emerging clinical experience suggest accelerated post-surgical healing, though controlled human trial data remain limited

A deficiency in Vitamin B12 can exacerbate this risk, leading to a type of anemia known as megaloblastic anemia

Further, these same potency effects extend to other properties of IGF-1 as well, including its anabolic effects on skeletal muscle and its neuroprotective effects