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Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

demonstrated that polymorphism of the optic atrophy 1 (OPA1) gene, which encodes a dynamin-related mitochondrial protein, was related to the pathology of OAG.[43] Additionally, we previously showed that mitochondrial DNA damage in blood cells, represented by an increased mitochondrial/nuclear DNA (mtDNA/nDNA) ratio, was associated with abnormal BF (MBR) in the ONH in glaucoma patients.[44] Taking these past results together with those of this study, it is thus reasonable to consider that systemic mitochondrial dysfunction influences hemodynamics in the ONH

A 2-week time-restricted feeding attenuates psoriasis-like lesions with reduced inflammatory cytokines and immunosenescence in mice

On the basis of our findings in those patients and on published experience, we concluded that anaphylactoid reactions to intravenous NAC are dose-related and the antihistamines are useful in controlling and in preventing recurrence of anaphylactoid symptoms

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

112 NishinoI.SpinazzolaA.PapadimitriouA.HammansS.SteinerI.HahnC