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Shamsah AH, Cartmell SH, Richardson SM, et al

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The CNS is specifically endowed with widely disrtributed melatonin receptors with the advantage of melatonin being directly secreted into the cerebrospinal fluid (CSF) [198]

In vitro experiments showed that radiation can induce the ratio of ROS levels and RANKL to OPG in osteoclast precursor cells (RAW 264.7), prompting the differentiation of RAW 264.7 into osteoclasts