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In preclinical investigations, CDK4/6 inhibitors have enhanced apoptosis, caused cellular senescence, reduced DNA damage repair, and arrested the cell cycle, all of which have radiosensitized cancer cells (Franco et al

The latter pain source is a puzzle to the surgeon

It is crucial to monitor these effects and adjust treatment as necessary

Normal BMP signaling protects the neuromuscular junction (NMJ) and prevents excessive denervation of muscle fibers, and disturbed BMP signaling accelerates muscle atrophy (171, 174)