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Schuurman M, et al

Doctors can reduce doses, increase intervals, or change ingredients to ensure safety

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Similarly, this is also seen in the setting of many chronic diseases such as metabolic syndrome and diabetes [3,4], atherosclerosis and cardiovascular disease [5], chronic kidney disease [6], neurodegenerative conditions such as Alzheimers disease and Parkinsons disease [7-9], as well as autoimmune diseases [10], cancer [11] and chronic infections such as human immunodeficiency virus [12]

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Yet, it is unknown if this formulation would exert primarily local effects on the digestive system, or if it would work systemically