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Alternative technologies for administering vaccines may yield greater mucosal targeting of immunity

Blocking IL-23 results in a downstream block of IL-22 and pathogenic Th17 cells involved in bone loss pathogenesis

NMN pretreatment in a rat model of IRI, in this case caused by occlusion of the left anterior descending coronary artery (LADCA), proved to improve myocardial function and decrease infarct size, also decreasing ROS levels and improving mitochondrial activity [226], while another murine model for LADCA-ligation IRI (LADCA-IRI) showed that NMN pretreatment protected the heart from IRI in both ischemia and reperfusion phases, by reducing infarct area [227]