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The efficacy of B-017 was also evident in staurosporine-treated HepG2 and MCF-7 cells (Supplementary Fig

Indeed, although our screen indicates a decrease in total cell count upon treatment, suggesting a cytotoxic effect, there was limited change to variant distribution, suggesting that there was a global decrease in the population rather than a specific sub-population of sensitive mutants

71 In addition, GPX4 plays important role in the survival of drug resistant cancer cells

Usage Cited in: Nucleic Acids Res

Cancer 136 , E39E50 (2015)