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De Forni et al., Synergistic drug combinations designed to fully suppress SARS-CoV-2 in the lung of COVID-19 patients, PLoS ONE, doi:10.1371/journal.pone.0276751

If it does not, the 21-day limit is a reasonable starting point, but only if your room temperature genuinely stays below 86 degrees Fahrenheit

doi: 10.1016/j.neulet.2016.06.011 18 BiaeckaM.KurzawskiM.RoszmannA.RobowskiP.SitekE.HonczarenkoK.et al

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Switching nostrils each dose can help

Watch for any bruising or bleeding issues if on higher doses or with other blood thinners (though issues are rare at these doses)