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give the actives their well-needed pause to deliver that top-notch performance

7gj and Supplementary Tables 22 and 23)

Research shows that p53 plays dual roles in both promoting and inhibiting ferroptosis: on the one hand, it promotes ferroptosis by downregulating the expression of SLC7A11, a negative ferroptosis regulator, and by enhancing the expression of spermidine/spermine N1-acetyltransferase 1 (SAT1), which upregulates ALOX15 expression to drive lipid peroxidation [142]