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2018 Sep 20;8(3):97-104

Intra-cellular localization of the biosynthetic pathway to flavor precursors in onion

Furthermore, Mueller et al

In mitochondria, THF is imported via a mitochondrial folate transporter and converted into 5,10-methylene-THF by serine hydroxymethyltransferase 2 (SHMT2), which oxidizes serine to glycine while transferring a one-carbon unit to THF [15]

Expectations should adjust accordingly

They found that ASAH2 inhibition in colorectal cancer cells leads to decreased GSK3 phosphorylation and activation of AKT, a critical cell growth target