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Water is employed as a single solvent in the reaction, but in order to enhance the solubility of (S)-3-activated hydroxybutyrolactone as the starting material, an organic co-solvent with water may be utilized, such as alcohol of C 1 4 , tetrahydrofuran, or acetonitrile

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MT-1 is a linear 13-amino acid peptide approved for erythropoietic protoporphyria

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Food- and microbiota-derived metabolites can be absorbed through the gut and subsequently modulate immune responses and metabolism 5,6,7

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