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Gentamicin protection assays confirmed their viable intracellular state, and intracellular CFU counts increased over time for hvKp but not for non-hypervirulent isolates, highlighting a specific capacity for resistance to tissue macrophage clearance

doi:10.3390/molecules25030609

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In a study [474] where mice were divided into six groups (control, model, 5-ASA, and SCH at varying doses), SCH-treated mice showed substantial weight gain, alleviated colitis severity, decreased inflammatory factors, and improved gut microbiota (GM) composition and bile acid conversion, suggesting SCH's potential as a UC treatment through the regulation of the SGK1/NLRP3 pathway and GM balance