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Since nasal spray requires higher doses to achieve equivalent systemic levels, peptide consumption increases

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When glycine binds to inhibitory glycine receptors (chloride-channel complexes), it causes an influx of chloride ions into neurons, hyperpolarizing the cell membrane and thereby reducing neuronal excitability

To assess whether MitoQ treatment can similarly overcome the differentiation block observed with DPI (16), MNA IMR-5/75 cells were treated every two days with either 50 nM or 100 nM MitoQ and monitored by microscopy ( Figure 1G )