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pointed out that in vivo and in vitro experiments, heat stress can ultimately induce hepatocyte pyroptosis by mediating the activation of the HMGB1 signaling pathway [26]

10.3390/nu8080515 Summary Keywords antagonistic effect, polyphenols, cisplatin, signalling pathway, apoptosis Citation Han S, Sun J, Li W, Li J, Yu H, Wang S and Chi Y (2025) Studies on the mechanism of ototoxic action of cisplatin and the antagonistic effect of polyphenolic compounds

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BDNF is a key neurotrophic factor that plays a central role in neuronal survival, growth, and synaptic plasticity

That is a clear signal that continuous use prevents the rebound that typically follows weight loss through dieting or other means

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