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268 A meta-analysis of 16 studies noted chronotherapies improve depression more quickly than antidepressants, psychotherapy, or exercise, reducing symptoms by 50% or more in 33% of patients after 57 days

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Promising classes include: Protein biomarkers : -synuclein (total and phosphorylated), neurofilament light chain (NfL), DJ-1

2020:11 Rai SN, Singh P, Varshney R, Chaturvedi VK, Vamanu E, Singh MP, Singh BK (2021) Promising drug targets and associated therapeutic interventions in Parkinsons disease