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Astrocytes derived from C9orf72 and sporadic ALS patients were found to be toxic in vitro and in vivo to motor neurons, by a non-cell-autonomous mechanism (Di Giorgio et al., 2007

W.GorospeJ.CummingsM.CowardS.BuieM

doi: 10.1172/JCI147822 103 LiuRLiXHylemonPBZhouH

In the direct comparison of iNs_D14 to iNs_D7, we observed the most substantial upregulation in glycerophospholipid metabolism, consistent with ongoing membrane remodeling during neuronal maturation, while glycolysis and gluconeogenesis pathways were downregulated (Online Resource 1Fig