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For instance, the common but less severe ones include nausea, breast tenderness, and headachesall likely to be reduced with continued use

TT genotype of the methylenetetrahydrofolate reductase C677T polymorphism is an important determinant for homocysteine levels in multi-ethnic Malaysian ischaemic stroke patients

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Curr Drug Targets CNS Neurol Disord 4 , 657665 (2005)

Topical applications are often once or twice daily, while injectable protocols might be daily or every other day