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By targeting NNMTan enzyme highly expressed in adipose tissue and linked to insulin resistancethis compound allows researchers to explore how shifting cellular metabolism away from fat storage toward energy utilization can impact systemic health

This occurs in conditions such as pernicious anemia, an autoimmune condition that affects the production of intrinsic factor, which is necessary for the absorption of B12 in the small intestine

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In severe cases, the body may struggle to absorb enough of the vitamin from oral sources leading to continued symptoms of deficiency

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however, to date, every attempt to develop selective thyroid hormone receptor agonists which are effective in adipose tissue without systemic side-effects has failed