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Mitochondria serve as primary sensors of cellular stress, and subtle shifts in their function, particularly the generation of reactive oxygen species (ROS), act as potent upstream signals that activate the MAPK cascade (66)

doi: 10.1080/07352689.2024.2315710 79 LeidaC.MoserC.EsterasC.SulpiceR.LunnJ

Deficiencies of either vitamin B6 or vitamin B12 result in altered homocysteine metabolism and increased homocysteine concentrations (136, 323), which are detrimental to cardiovascular health (2, 216, 331)