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reported that astrocyte ablation in chronic experimental autoimmune encephalomyelitis ameliorates pathology, whereas acute-phase ablation worsens disease, illustrating a time-dependent dual role 37

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Reduced dACC glutamate in the Established but not the Recent group could point to a range of potentially abnormal process in schizophrenia such as altered glutamate synthesis, turnover, reuptake or astroglial function other than the proposed accumulation of damage to glutamate synapses in established schizophrenia [4, 6, 44]