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Although the tobacco industry consistently argues that tax and price increase may lead to contraband [42], an analysis of cigarette prices and levels of smuggling in Iran [19] and sixteen European countries found no correlation between the increase in tobacco prices or taxation and rates of smuggling tobacco activity [42]

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Chronic smoking also leads to the formation of atheromatous plaques due to increased expression of matrix metalloproteinases (MMP), particularly MMP-12 and MMP-9 in macrophages, MMP-8 and MMP-9 in endothelial cells, and MMP-2 and MMP-9 in vascular smooth muscle cells ( 35 , 36 )

Gazing into the Crystal Ball: The Future of Tobacco Cultivation As we cast our gaze toward the future, the landscape of tobacco cultivation is poised for transformation