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Sirtuins, particularly SIRT1 [60], SIRT2 [61], and SIRT3 [62], decline with age

The amount of -ketobutyrate, which was generated during the enzymatic reaction, was quantified with 3-methyl-2-benzothiazolinone hydrazine hydrochyperlipidemiaoride as the description of previous studies [28]

doi: 10.3892/ijmm.2019.4418 43 DyllaSJ

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These findings highlight the value of bright, photostable far-red dyes like CF647 for imaging-driven validation of targeted immunotherapies