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50,51 Overall, SIRT1 functions as a key metabolic sensor and epigenetic regulator, with both expression and enzymatic activity finely tuned by internal and external cellular signals

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Patients have high GT levels, normal cholesterol levels, and normal or mildly elevated BA concentrations

10.1007/s12017-015-8359-5 80

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Diabetes 50 , 227232 (2001)