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Without a systematic concept and detailed molecular knowledge, ferroptosis was attributed to the other existing forms of cell death and was considered to have no biological significance

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Acknowledgements The authors thank Professor Genji Qin (Peking University, China) for providing the vps29 mutant and Professor Ruixi Li (South University of Science and Technology, China) and Professor Caiji Gao (South China Normal University, China) for providing the snx1/snx2a/snx2b mutant

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A particularly promising approach involves combining inhibitors of PC metabolism with direct ferroptosis inducers