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doi: 10.3389/fimmu.2022.1051161 Received 22 September 2022 Accepted 02 November 2022 Published 21 November 2022 Volume 13 - 2022 Edited by Maria Carolina Accioly Brelaz de Castro, Federal University of Pernambuco, Brazil Reviewed by Anna E van Beek, Sanquin Diagnostic Services, Netherlands

doi: 10.1039/C6FO01498D 41 KnazeVZamora-RosRLujn-BarrosoLRomieuIScalbertASlimaniNet al

TXNIP then directly binds to and activates the NLRP3 inflammasome (Zhou et al., 2010

In another study, researchers revealed that bone marrow mesenchymal stem cells extracted from ALS patients exhibited a decrease in AMPK/SIRT1 signaling, which was subsequently restored through resveratrol treatment [75]