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Claims that a product crosses the bloodbrain barrier are often based on labelled cultured-cell experiments rather than human pharmacokinetic evidence

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The most reproducible single mechanism is non-canonical activation of the VEGFR2-Akt-eNOS axis : Hsieh and colleagues showed that BPC-157 induces VEGFR2 internalization and downstream signaling in endothelial cells in the absence of VEGF, supporting capillary outgrowth in the wound bed

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Osanai, M., Murata, M., Nishikiori, N., Chiba, H., Kojima, T