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Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

Results MB is a more potent ROS scavenger than NAC, MitoQ, and mTEM To evaluate the effectiveness of MB as an antioxidant, we first compared the effects of MB treatment with the effects of three other popular ROS scavengers, specifically, N-Acetyl-L-cysteine (NAC), MitoQ, and MitoTEMPO (mTEM)

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At the vascular and interstitial level, pathological angiogenesis and altered fluid dynamics restrict the entry of blood-borne carriers into the tumor and make their distribution within the tissue highly uneven [31,32,33]