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& Tyagi, A

This deficiency is speculated to be due to the loss of microorganisms (dubbed the hygiene hypothesis or Old Friends hypothesis ) from modern urban environments, with which humans have coevolved and tolerated and relied on for the development of immunoregulatory circuits [454]

Proc Natl Acad Sci USA 99(22):1442814433 Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M (2003) Attenuation of Helicobacter pylori CagA SHP-2 signaling by interaction between CagA and C-terminal Src kinase

The VN can capture alterations in the gut microbial ecology and transmit these to the central nervous system, which will trigger adaptive or maladaptive responses the latter potentially leading to gastrointestinal diseases or neurodegenerative diseases (270)

10.1007/s12551-018-0496-2

Comparative effects of garlic (Allium sativum) powder and atorvastatin in female reproductive system of hypercholesterolemic rats: a histological and biochemical evaluation