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Avoid agitation and repeated handling to minimize degradation

The mechanisms by which certain medications bring about oral mucosal melanin hyperpigmentation include upregulation of tyrosinase activity, deposition of complexes of the drug with pre-existing melanin in the mucosa, or induction of local inflammatory reactions with the triggering of melanin production [11, 38]

The side effect profile is also comparatively mild because it doesn't significantly activate the other melanocortin receptors scattered throughout the body

This melanin-increasing function is its most notorious, but the drug has several otherpotentially dangerouseffects and has been reported to cause heart, blood, and eye disorders, among other conditions

This association should be considered in those middle aged or older who lack endocrinopathy, are nonobese, have appreciable pruritus, or have a recent history of unintentional weight loss

Dr Skerritt said it was an important move to protect the public from misinformation