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Ook niet-genfecteerde cellen lijden aan mitochondrile disfunctie als gevolg van (lokale, systemische) oxidatieve stress en chronische ontsteking, verstoring van de calciumstofwisseling en het vrijkomen van pro-oxidatief ijzer en pro-inflammatoire celfragmenten (waaronder geoxideerd mitochondriaal DNA) uit dode, uiteengevallen cellen