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227 The nitroimidazole moiety acted as a hypoxia-sensitive trigger that underwent bioreduction in low-oxygen environments to facilitate doxorubicin release, while Ce6 generated reactive oxygen species (ROS) under laser irradiation

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Additionally, 1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed