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The lateral habenula is a key projecting region to DA neurons and has a major role in the neurocircuitry of aversion with its indirect inhibitory control [47, 68, 69] and direct excitatory control over the VTA and SNc [70, 71]

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40 An observational cohort of 1200 people with fentanyl-positive urine receiving emergency department-initiated buprenorphine reported only 9 episodes of precipitated withdrawal

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