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ROWAN JACOBSEN: Why

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In brain ischemiareperfusion injury, using PARP-1 inhibitors (such as PJ-34, Olaparib) can mitigate H 2 O 2 /O/OH accumulation, prevent neuronal damage, and enhance neurological recovery [253]

Recent studies have indicated that the absence of other amino acids, such as arginine, prevents cysteine depletion from triggering ferroptosis, highlighting the complementary roles of multiple amino acids in modulating iron-death [104]

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Low levels of SA, resulting from dietary intake of SA and endogenous synthesis from benzoic acid/benzoate, might have led to the emergence of multiple SA targets in animals, as in plants, some of which are common to both kingdoms