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Rare but serious risks include pancreatitis, gallbladder disease, acute kidney injury (secondary to dehydration from GI effects), and a theoretical thyroid C-cell tumor risk based on rodent data that has not been confirmed in human post-marketing surveillance

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[3] Some individuals report experiencing acne breakouts after starting B12 supplements or receiving injections, though this appears to be relatively uncommon

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Compounders have not shared any data on the new molecule produced from the interaction of tirzepatide and vitamin B12, so we dont know what its safety profile is or whether it could affect how well the medication works, Moreno says