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There are three isoforms of NOS: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) [50]

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While iron and transferrin have been shown to induce hepatic stellate cell activation and collagen expression in vitro [86,87,88], in vivo models of iron overload demonstrate only minor fibrosis, although the numbers of alpha-smooth muscle actin (SMA)-positive myofibroblasts were significantly increased [89, 90]

doi: 10.3389/fnins.2020.00380 30 van der DeureWMPeetersRPVisserTJ